I guess it depends on the drawing. I know that back when I was thinking of creating a comic story with some of my OCs (with Amelie being the main character and Kasumi being a supporting character), I wasn't gonna have any fourth-wall breaking or anything like that. But I have my OCs breaking the fourth-wall here and there in different pieces of artwork I've done over the years. I can't really quantify how well any of them are at breaking the fourth-wall, as it just depends on the picture I'm drawing and what I'm trying to do with said picture.