-Jinx "character development" will be forced through making her care about some random kid
-Vi's motivations will make no sense and be boiled down to fanservice with caitlyn
-Ekko will be tantamount to a deus ex machina

sorry negative lol :') more obscure predictions maybe: Jinx will become more than human through the anomaly, the anomaly will combine with the z-drive and include things like time travel and multiverses, Vander will only become doggy after Vi or Jinx kill him, Vi will still get amnesia (enemies flavor text makes me suspicious) and Jinx might also. Random thing I hope happens but probably wont: Heimer builds his hexrex.