They marry their 13-year-old cousin like Jerry Lee Lewis?
Madonna isn't relevant since ages if you ask me. When she reinvented herself her music and personal expression went from relevant to artificial, plastic, fake, irrelevant at a fast pace. At least this was it for me. My rule of thumb is when an entertainer appears on stage and changed into a glitter cowboy type in Vegas. Whenever an artist does it I take it as a sign of burn-out and loss and being not relevant any more. A last cry for help while drowning by the huge weight of the glitter and a Stetson in pink.
Just because they're retired (or even dead) doesn't necessarily make them no longer relevant. I guess you know they're no longer relevant because nobody talks about them anymore. But then, some people are still legends in our minds (or in the minds of older generations) like Madonna even though they're not popular anymore. I don't know.
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