After making through the ordeal, except we don't know where the end of it is.

Id say when you finally get a grasp on how the universe works and how to use its laws to your advantage

probably what Shannon said; when you die. =P

It doesn’t. It’s just that it gets easier and harder in different ways. The universe has no interest in keeping us too comfortable.

when you give up and stop wearing pants

The more you throw overboard and the lighter your boat the more easy it gets.

When we are dead

In five years.